反応 #2025287

反応方程式

ethyl acetate

NaOH

(-)-4-acetoxy-4'-(2-propoxypropyl)biphenyl

hydrochloric acid

→

(-)-4-hydroxy-4'-(2-propoxypropyl)biphenyl

収率 101.7%

溶媒

methanol

反応条件

後処理

1. 1
   その他After completion of the reaction
2. 2
   抽出extraction treatment
3. 3
   洗浄washed
4. 4
   濃縮concentrated under a reduced pressure

実験手順

Then, 2.5 g (8 mM) of the thus-obtained (-)-4-acetoxy-4'-(2-propoxypropyl)biphenyl was dissolved in 30 ml of methanol, added with 20% NaOH aqueous solution, and sturred at room temperature for 2 hrs. After completion of the reaction, the reaction solution was added with 1N hydrochloric acid till pH 2-3, and then further added with 100 ml of ethyl acetate to subject extraction treatment. The resulting organic layer was water-washed and then concentrated under a reduced pressure to obtain 2.2 g of (-)-4-hydroxy-4'-(2-propoxypropyl)biphenyl (V-43) with 100% yield.

出典