反応 #2021470

反応方程式

2-methyl-2-adamantanol

triethylamine

methacryloyl chloride

→

2-methyl-2-adamantyl methacrylate

収率 75.0%

溶媒

methyl isobutyl ketone

反応条件

後処理

1. 1
   workup.ADDITIONwas added
2. 2
   その他to form a solution
3. 3
   ろ過After filtration
4. 4
   洗浄the organic layer was washed with 5% aqueous sodium hydrogen carbonate solution
5. 5
   洗浄washed twice with water
6. 6
   濃縮The organic layer was concentrated
7. 7
   workup.DISTILLATIONdistilled under reduced pressure

実験手順

Into a reaction vessel were charged 83.1 parts of 2-methyl-2-adamantanol and 101 parts of triethylamine, and 200 parts of methyl isobutyl ketone was added thereto to form a solution. To this solution was added dropwise 78.4 parts of methacryloyl chloride (1.5 mole based on 2-methyl-2-adamantanol). The solution was stirred at room temperature for about 10 hours. After filtration, the organic layer was washed with 5% aqueous sodium hydrogen carbonate solution and then washed twice with water. The organic layer was concentrated and distilled under reduced pressure to give 2-methyl-2-adamantyl methacrylate represented by the following formula in 75% yield:

出典