反応 #2021467

反応方程式

HCl

4-fluorobenzaldehyde

malonic acid

piperidine

→

4-fluorocinnamic acid

溶媒

pyridine

反応条件

後処理

1. 1
   温度cooled
2. 2
   濃縮a 10% concentration
3. 3
   ろ過The precipitate is filtered
4. 4
   その他crystallized with ethanol

実験手順

A mixture of 0.1 mol 4-fluorobenzaldehyde, 0.15 mol malonic acid, and 0.1 ml piperidine in 30 ml pyridine is boiled for 10 hours, cooled, and treated with 150 ml HCl having a 10% concentration. The precipitate is filtered and crystallized with ethanol. The yield of 4-fluorocinnamic acid is 68% and the melting point is 211° C.

出典