反応 #2007672

反応方程式

Mesityl-2-fluorophenyl iodonium triflate

sodium trifluoromethanesulfinate

→

title compound

1-fluoro-2-((trifluoromethyl)sulfonyl)benzene

溶媒

N,N-dimethylformamide

反応条件

後処理

1. 1
   その他equipped with a magnetic stir bar
2. 2
   その他the reactor was capped
3. 3
   その他HPLC analysis of the crude reaction mixture

実験手順

Mesityl-2-fluorophenyl iodonium triflate (Sanford M et al. JACS, 2005, 127, 7330 and Widdowson, D. et al. Tetrahedron Letters 2000, 41, 5393.) (0.1 g, 0.204 mmol), sodium trifluoromethanesulfinate (0.035 g, 0.224 mmol) and copper(I) oxide (2.92 mg, 0.020 mmol) were weighed into a reactor equipped with a magnetic stir bar. N,N-dimethylformamide (1 mL) was added, the reactor was capped and heated at 25° C. for 24 hours. HPLC analysis of the crude reaction mixture indicated the formation of the title compound.

出典