反応 #2006486

反応方程式

compound 25

1-Benzyl-4-(2-hydroxy-ethyl)-piperidin-4-ol

charcoal

→

desired compound 26

収率 102.7%

4-(2-Hydroxy-ethyl)-piperidin-4-ol

収率 102.7%

溶媒

methanol

反応条件

後処理

1. 1
   その他The solution was purged three times with hydrogen
2. 2
   ろ過The resulting solution was then filtered on celite plug

実験手順

To a solution of compound 25 (1.32 g, 5.30 mmol) in methanol (10 mL) under argon was added palladium hydroxide (20%) on activated charcoal (132 mg, 10% w/w). The solution was purged three times with hydrogen and stirred under hydrogen atmosphere at 60° C. for 4 hrs. The resulting solution was then filtered on celite plug to give desired compound 26 (790 mg, 94%) which was used as such for the next step.

出典