反応 #2006454

反応方程式

sodium hydroxide

N-benzyl-3-aminopiperidine

→

(R)—N-benzyl-3-aminopiperidine

反応条件

後処理

1. 1
   その他After the reaction liquid
2. 2
   抽出was extracted with 1 L of toluene
3. 3
   抽出was then further extracted from the aqueous phase with 1 L of toluene
4. 4
   workup.DISTILLATIONAfter the solvent had been distilled under reduced pressure away from a combination of the organic phases
5. 5
   その他thus obtained
6. 6
   workup.DISTILLATION(R)—N-benzyl-3-aminopiperidine was purified by distillation

実験手順

After the reaction liquid had been adjusted to a pH of 13 by the addition of 5 N aqueous solution of sodium hydroxide, N-benzyl-3-aminopiperidine was extracted with 1 L of toluene, and was then further extracted from the aqueous phase with 1 L of toluene. After the solvent had been distilled under reduced pressure away from a combination of the organic phases thus obtained, (R)—N-benzyl-3-aminopiperidine was purified by distillation. Thus, 17.7 g of (R)—N-benzyl-3-aminopiperidine were obtained in the form of colorless oil.

出典