反応 #2006439

反応方程式

hydrogen

cyclopentadiene

cyclopentadiene

bromine

hydrogen peroxide

NaOH

bromine

→

alcohol

1-Cyclopentylcyclopentanol

溶媒

tetrahydrofuran

tetrahydrofuran

tetrahydrofuran

methanol

反応条件

後処理

1. 1
   その他To a 1000-mL 3-necked round bottom flask equipped with a 250-mL pressure
2. 2
   workup.ADDITIONaddition funnel, a nitrogen inlet with thermocouple and an overhead stirrer
3. 3
   その他The flask was immersed in an ice-water bath
4. 4
   その他The solvent was then removed under reduced pressure
5. 5
   その他the remaining oil transferred to a 5 L 3-necked round bottom flask
6. 6
   その他equipped with a thermocouple inlet
7. 7
   workup.ADDITIONoverhead stirrer and a 500-mL addition funnel
8. 8
   workup.ADDITIONDichloromethane (2 L) and water (500 mL) were added
9. 9
   workup.ADDITIONwas then added slowly over 1 hr
10. 10
    その他was recooled to 5° C.
11. 11
    workup.STIRRINGAfter stirring overnight at room temperature the organic layer
12. 12
    その他was separated
13. 13
    洗浄washed several times with water
14. 14
    乾燥once with brine and then dried over anhydrous magnesium sulfate for 1 hour
15. 15
    ろ過Filtration and removal of the solvent at reduced pressure
16. 16
    その他resulted in a light-colored oil which
17. 17
    workup.DISTILLATIONwas distilled from Na2CO3 through a short Vigreux (bp 63° C.@ 1 mmHg)

実験手順

To a 1000-mL 3-necked round bottom flask equipped with a 250-mL pressure equalizing addition funnel, a nitrogen inlet with thermocouple and an overhead stirrer was added 172 mL (1.72 mol) of a 10M solution of BH3-Me2S in tetrahydrofuran and 300 mL of dry tetrahydrofuran. The addition funnel was charged with 116.8 g (1.72 mol) of cyclopentadiene dissolved in 100 mL of dry tetrahydrofuran. The flask was immersed in an ice-water bath and the cyclopentadiene solution slowly added over 2 hours at 0-5° C. Stirring was continued for an additional 90 min at this temperature at which time 130 mL of methanol was cautiously added over 1 hour with vigorous evolution of hydrogen. The solvent was then removed under reduced pressure and the remaining oil transferred to a 5 L 3-necked round bottom flask equipped with a thermocouple inlet, overhead stirrer and a 500-mL addition funnel. Dichloromethane (2 L) and water (500 mL) were added and the mixture cooled to 5° C. The addition funnel was charged with 100 mL (1.95 mol) of bromine which was then added slowly over 1 hr. The resulting dark mixture was exposed to a long wave UV lamp with stifling at room temperature overnight by which time the bromine color had largely disappeared. The reaction mixture was recooled to 5° C. and 1.3 L of 6N NaOH was added slowly via the addition funnel followed by 400 mL of 30% hydrogen peroxide. After stirring overnight at room temperature the organic layer was separated, washed several times with water, once with brine and then dried over anhydrous magnesium sulfate for 1 hour. Filtration and removal of the solvent at reduced pressure resulted in a light-colored oil which was distilled from Na2CO3 through a short Vigreux (bp 63° C.@ 1 mmHg) to yield 72 g (55%) the title alcohol as a clear, colorless oil.

出典