反応 #2006429

反応方程式

H2O

2-(6-Methyl-2-pyridyl)imidazole

sodium t-butoxide

N-(6-bromohexyl)phthalimide

→

2-(6-methyl-2-pyridyl)-1-(6-(phthalimido)hexyl)imidazole

溶媒

DMF

反応条件

後処理

1. 1
   workup.WAITat 60° C. for 3.5 h
2. 2
   抽出extracted three times with EtOAc (3×100 mL)
3. 3
   抽出The combined EtOAc extract
4. 4
   乾燥was dried with anhydrous Na2SO4
5. 5
   その他evaporated to dryness
6. 6
   その他The product was purified by a silica gel column

実験手順

To a solution of 2-(6-Methyl-2-pyridyl)imidazole (2.16 g) and sodium t-butoxide (1.57 g) in 50 mL dry DMF was added N-(6-bromohexyl)phthalimide (4.72 g). The resulting solution was stirred at room temperature for 3 h and then at 60° C. for 3.5 h. The solution was poured into H2O (80 mL) and then extracted three times with EtOAc (3×100 mL). The combined EtOAc extract was dried with anhydrous Na2SO4, and then evaporated to dryness. The product was purified by a silica gel column using EtOAc as the eluent. Yield: about 4.2 g.

出典