反応 #2006426

反応方程式

methyl iodide

compound 28

4-(Benzenesulfonylamino)-phenyl Iodide

K2CO3

→

title compound

収率 196.6%

N-Methyl-4-iodophenylbenzenesulfonamide

収率 196.6%

溶媒

DMF

反応条件

後処理

1. 1
   その他The resulting reaction mixture
2. 2
   その他The solvent is then removed
3. 3
   workup.ADDITIONwater was added
4. 4
   抽出The resulting mixture was extracted with ethyl acetate
5. 5
   その他the combined organic phases were dried
6. 6
   濃縮concentrated
7. 7
   その他Purification by flash chromatography

実験手順

To compound 28 (from Example 18) (500 mg, 1.39 mmol) in DMF (10 mL) were added at room temperature K2CO3 (962 mg, 6.96 mmol), followed by methyl iodide (395 mg, 2.78 mmol). The resulting reaction mixture was stirred at room temperature for 16 hours. The solvent is then removed and water was added. The resulting mixture was extracted with ethyl acetate, and the combined organic phases were dried and concentrated. Purification by flash chromatography using hexane:ethyl acetate (8:2) afforded 510 mg (98%) of the title compound as a white solid.

出典