反応 #2006419

反応方程式

HCl

methyl ester

Methyl-4-(3-oxo-3-phenylpropyl)-benzoate

LiOH

→

title compound

4-(3-oxo-3-Phenylpropyl)-benzoic Acid

溶媒

water THF

反応条件

後処理

1. 1
   抽出the solution was extracted with EtOAc
2. 2
   乾燥the organic layer was dried over anhydrous MgSO4
3. 3
   ろ過Filtration and evaporation of the solvent under vacuum
4. 4
   その他followed by purification by column chromatography

実験手順

To a solution of methyl ester 47 (195 mg, 0.73 mmol) in water/THF (1:1, 0.07M) was added LiOH (46 mg, 1.1 mmol). The resulting solution was stirred overnight at room temperature or until no starting material was detected by TLC. HCl 1N was added and the solution was extracted with EtOAc and the organic layer was dried over anhydrous MgSO4. Filtration and evaporation of the solvent under vacuum followed by purification by column chromatography using 10% MeOH/CH2Cl2, gave the title compound.

出典