反応 #2000409

反応方程式

ethyl 3-oxo-3-(1,4-dioxaspiro[4.5]decan-8-yl)propanoate

3-amino-1H-pyrazole

→

5-(1,4-dioxaspiro[4.5]decan-8-yl)pyrazolo[1,5-a]pyrimidin-7-ol

溶媒

EtOH

反応条件

後処理

1. 1
   workup.ADDITIONThe mixture was mixed
2. 2
   その他to remove water
3. 3
   その他formed during cyclization
4. 4
   その他This solid was taken forward without further purification

実験手順

To a 20 mL scintillation vial containing ethyl 3-oxo-3-(1,4-dioxaspiro[4.5]decan-8-yl)propanoate (Int-5d, 11.7 mmol, 3.00 g) was added 3-amino-1H-pyrazole (11.7 mmol, 973 mg). The mixture was mixed and heated neat at 100° C. for 3 hours. The resulting off-white solid was taken up in EtOH (100 mL) and reduced in vacuo to remove water formed during cyclization. This solid was taken forward without further purification.

出典