反応 #1998

反応方程式

Water

triethylamine

5-phenyltetrazole

triphenylmethyl chloride

→

product

収率 100.0%

5-Phenyl-2-trityltetrazole

収率 100.0%

溶媒

acetone

tetrahydrofuran

反応条件

後処理

1. 1
   workup.STIRRINGthe mixture stirred for one hour at room temperature
2. 2
   ろ過The product was collected by filtration
3. 3
   洗浄washed with 75 mL of water
4. 4
   その他dried at 60° C. under vacuum

実験手順

To a suspension of 5.0 g (34.2 mmol) of 5-phenyltetrazole in 55 mL of acetone was added 5.0 mL of triethylamine (3.6 g, 35.6 mmol, 1.04 eq). After 15 minutes, a solution of 10.0 g of triphenylmethyl chloride (35.9 mmol, 1.05 eq) in 20 mL of tetrahydrofuran was added and the mixture stirred at room temperature for one hour. Water (75 mL) was slowly added and the mixture stirred for one hour at room temperature. The product was collected by filtration, washed with 75 mL of water and dried at 60° C. under vacuum to give 13.3 g (34.2 mmol, 100%) of the product.

出典