反応 #1994329

反応方程式

7-[2-(3-chloro-pyridin-2-yl)-5-methoxy-2H-pyrazol-3-yl]-2-(4-methoxy-benzyl)-5-methyl-2H-8-oxa-1,2,6-triaza-cyclopenta[a]naphthalen-9-one

→

6-{[2-(3-chloro-pyridin-2-yl)-5-methoxy-2H-pyrazole-3-carbonyl]-amino}-2-(4-methoxy-benzyl)-5-methyl-2H-indazole-7-carboxylic acid isopropyl amide

溶媒

tetrahydrofurane

反応条件

後処理

1. 1
   その他The reaction mixture was evaporated
2. 2
   その他the crude product was purified by flash chromatography on silica gel using
3. 3
   workup.ADDITIONa mixture of 75% ethyl acetate 25% cyclohexane

実験手順

A solution of 7-[2-(3-chloro-pyridin-2-yl)-5-methoxy-2H-pyrazol-3-yl]-2-(4-methoxy-benzyl)-5-methyl-2H-8-oxa-1,2,6-triaza-cyclopenta[a]naphthalen-9-one (0.100 g, 0.189 mmol) in tetrahydrofurane (2 ml) was treated with 16 drops of isopropyl amine and stirred at 20° C. for three hours. The reaction mixture was evaporated and the crude product was purified by flash chromatography on silica gel using a mixture of 75% ethyl acetate 25% cyclohexane. The desired product showed the physical data reported in the corresponding table (P.34.).

出典