反応 #1994324

反応方程式

triethylamine

6-{[2-(3-chloro-pyridin-2-yl)-5-methoxy-2H-pyrazole-3-carbonyl]-amino}-5-methyl-2H-indazole-7-carboxylic acid isopropyl amide

cyanuryl fluoride

→

6-{[2-(3-chloro-pyridin-2-yl)-5-methoxy-2H-pyrazole-3-carbonyl]-amino}-2-(4,6-difluoro-[1,3,5]triazin-2-yl)-5-methyl-2H-indazole-7-carboxylic acid isopropylamide

溶媒

chloroform

反応条件

後処理

1. 1
   その他evaporated to dryness
2. 2
   その他separated from some less soluble material
3. 3
   その他evaporated
4. 4
   その他to give the compound

実験手順

To a solution of 6-{[2-(3-chloro-pyridin-2-yl)-5-methoxy-2H-pyrazole-3-carbonyl]-amino}-5-methyl-2H-indazole-7-carboxylic acid isopropyl amide (0.300 g, 0.641 mmol) in chloroform (2.0 ml) was added cyanuryl fluoride (2,4,6-trifluoro-1,3,5-triazine) (0.220 g, 1.669 mmol) followed by triethylamine (0.090 ml, 0.046 mmol). The reaction mixture was stirred at 20° C. for three hours, then evaporated to dryness and submitted to high vacuum. The residue was taken up in a small amount of chloroform and separated from some less soluble material, then evaporated to give the compound showing the physical data described in the table under P.43.

出典