反応 #1994319

反応方程式

6-{[2-(3-chloro-pyridin-2-yl)-5-methoxy-2H-pyrazole-3-carbonyl]-amino}-5-methyl-2H-indazole-7-carboxylic acid isopropylamide

diisopropylethylamine

chloro-methoxy-methane

→

title compound

6-{[2-(3-chloro-pyridin-2-yl)-5-methoxy-2H-pyrazole-3-carbonyl]-amino}-2-methoxymethyl-5-methyl-2H-indazole-7-carboxylic acid isopropylamide

溶媒

THF

反応条件

後処理

1. 1
   その他The resulting reaction mixture
2. 2
   濃縮The reaction mixture was concentrated in vacuo
3. 3
   その他Purification of the residue by flash-chromatography (SiO2, CH2Cl2/acetone 7:3)

実験手順

A mixture of 6-{[2-(3-chloro-pyridin-2-yl)-5-methoxy-2H-pyrazole-3-carbonyl]-amino}-5-methyl-2H-indazole-7-carboxylic acid isopropylamide (500 mg, 1.07 mmol) and diisopropylethylamine (225 μL, 1.2 mmol) in THF (10 mL) was treated dropwise with chloro-methoxy-methane (90 μL, 1.2 mmol). The resulting reaction mixture was stirred for 2 hours at ambient temperature. The reaction mixture was concentrated in vacuo. Purification of the residue by flash-chromatography (SiO2, CH2Cl2/acetone 7:3) afforded the title compound as a colorless crystalline solid. M.p. 148° C., LC/MS:512/514 (M+H)+.

出典