反応 #1994295

反応方程式

6-Amino-2-(4-chloro-2,5-difluorophenyl)pyrimidine-4-carboxylic acid methyl ester

N-chlorosuccinimide

→

title compound

収率 50.0%

6-Amino-5-chloro-2-(4-chloro-2,5-difluorophenyl)-pyrimidine-4-carboxylic acid methyl ester

収率 50.0%

溶媒

acetonitrile

反応条件

後処理

1. 1
   濃縮The reaction mixture was concentrated
2. 2
   その他the product purified by column chromatography (ethyl acetate/hexane gradient)

実験手順

6-Amino-2-(4-chloro-2,5-difluorophenyl)pyrimidine-4-carboxylic acid methyl ester (0.090 g, 0.3 mmol) and N-chlorosuccinimide (0.05 g, 0.37 mmol) were combined in 10 mL acetonitrile and heated at 40° C. for 18 hours. The reaction mixture was concentrated and the product purified by column chromatography (ethyl acetate/hexane gradient) to yield the title compound as an off-white solid (0.050 g, 50% yield): 1H NMR (CDCl3): δ 7.85 (dd, 1H), 7.22 (dd, 1H), 5.62 (br s, 2H), 4.01 (s, 3H).

出典