反応 #1994264

反応方程式

1-naphthol

2,2,2-trifluoroethyl p-toluenesulfonate

potassium carbonate

dimethyl sulfoxide

→

target compound

収率 78.7%

1-(2,2,2-trifluoroethoxy)naphthalene

収率 78.7%

溶媒

toluene

water

反応条件

後処理

1. 1
   温度was heated
2. 2
   温度After cooling
3. 3
   洗浄It was washed 5 times with 100 g of 5 wt % sodium hydroxide aqueous solution
4. 4
   濃縮The organic layer was concentrated
5. 5
   その他obtaining 36 g of oily matter
6. 6
   workup.DISTILLATIONIt was distilled in vacuum (75° C./13 Pa)

実験手順

In a nitrogen atmosphere, a suspension of 34 g of 1-naphthol, 40 g of 2,2,2-trifluoroethyl p-toluenesulfonate, 33 g of potassium carbonate, and 80 g of dimethyl sulfoxide was heated and stirred at 100° C. for 12 hours. After cooling, 100 g of water and 200 g of toluene were added to the suspension, after which an organic layer was taken out. It was washed 5 times with 100 g of 5 wt % sodium hydroxide aqueous solution, then 4 times with 100 g of water. The organic layer was concentrated, obtaining 36 g of oily matter. It was distilled in vacuum (75° C./13 Pa), obtaining 28 g (yield 76%) of the target compound.

出典