反応 #1994258

反応方程式

10-(biphenyl-4-yl)-9,10-dihydroacridine

bromosuccinimide

→

10-(biphenyl-4-yl)-2-bromo-9,10-dihydroacridine

収率 77.7%

溶媒

chloroform

反応条件

後処理

1. 1
   洗浄the resultant solution was washed with distilled water
2. 2
   抽出Then, an organic layer was extracted
3. 3
   乾燥dried with sodium sulfate so as
4. 4
   その他to remove the solvent
5. 5
   その他The residue was purified by silica gel column chromatography (methylene chloride/n-hexane (1/20))

実験手順

The obtained 10-(biphenyl-4-yl)-9,10-dihydroacridine (15.3 g, 45.9 mmol) was added with chloroform (500 ml), and then with bromosuccinimide (9.8 g, 55.1 mmol). The resultant solution was stirred at room temperature for 2 hours. After the reaction was completed, the resultant solution was washed with distilled water. Then, an organic layer was extracted and dried with sodium sulfate so as to remove the solvent. The residue was purified by silica gel column chromatography (methylene chloride/n-hexane (1/20)) to obtain 10-(biphenyl-4-yl)-2-bromo-9,10-dihydroacridine compound (white solid, 14.7 g, yield 77%).

出典