反応 #1994252

反応方程式

water

carbazole

sodium hydroxide

allylbromide

→

N-Allylcarbazole

溶媒

dimethylsulfoxide

反応条件

後処理

1. 1
   抽出extracted with ethyl acetate
2. 2
   洗浄The ethyl acetate layer was washed with water
3. 3
   濃縮concentrated
4. 4
   その他The crude product was purified

実験手順

A mixture of 10.85 g (65.0 mmol) of carbazole, 2.60 g (65.0 mmol) of sodium hydroxide and 6.1 mL (72.0 mmol) of allylbromide in 100 mL dimethylsulfoxide was heated to 60° C. for 5 hours. The reaction mixture was poured into water and extracted with ethyl acetate. The ethyl acetate layer was washed with water and then concentrated. The crude product was purified using column chromatography (silica, 1:4 dichloromethane:hexane). Yield: 9.85 g (73%).

出典