反応 #1994248

反応方程式

8-nitro-2-naphthylquinoline

sodium borohydride

HCl

→

crystalline solid

収率 135.5%

8-Amino-2-naphthylquinoline

収率 135.5%

溶媒

methanol

反応条件

後処理

1. 1
   workup.STIRRINGAfter stirring for 2 h
2. 2
   その他The solvent is then removed
3. 3
   洗浄the resultant residue is washed vigorously with water
4. 4
   その他recrystallised from dioxane
5. 5
   ろ過The precipitate is filtered
6. 6
   その他dried in vacuo

実験手順

12.6 g (42 mmol) of 8-nitro-2-naphthylquinoline and 1.99 g of Pd/C (10%) are suspended in 200 ml of methanol. 8.4 g (222 mmol) of sodium borohydride are added in portions with stirring at 0° C. After stirring for 2 h, the clear solution is neutralised using dilute HCl. The solvent is then removed, and the resultant residue is washed vigorously with water and recrystallised from dioxane. The precipitate is filtered and dried in vacuo, giving 9.9 g (56.9 mmol) of crystalline solid. The overall yield is 88%.

出典