反応 #1994226

反応方程式

Boc-Gly Rotigotine HCl

trifluoroacetic acid

→

Gly Rotigotine

収率 79.0%

溶媒

dichloromethane

反応条件

後処理

1. 1
   その他all the volatiles were removed
2. 2
   その他a rotary evaporator
3. 3
   workup.DISSOLUTIONThe residue (dark yellow) was dissolved in methanol
4. 4
   その他precipitated
5. 5
   workup.ADDITIONby adding into diethyl ether (40 mL)
6. 6
   ろ過The pale yellow precipitate was filtered
7. 7
   その他dried

実験手順

The Boc-Gly-Rotigotine HCl was deprotected by first dissolving the product (1.258 g, 2.55 mmol) in dichloromethane (64 ml). After addition of trifluoroacetic acid (9.83 ml, 128 mmol), the reaction mixture was stirred for 1 hour at room temperature and then all the volatiles were removed using a rotary evaporator. The residue (dark yellow) was dissolved in methanol and precipitated by adding into diethyl ether (40 mL). The pale yellow precipitate was filtered using a glass frit and dried to give Gly-Rotigotine.2TFA (1.140 g, 79% yield).

出典