反応 #1990250

反応方程式

methyl 2-butynoate

2,3-dihydroxypropylamine

→

desired product

Methyl 3-(2,3-dihydroxypropyl)amino-2-butenoate

溶媒

ethanol

反応条件

後処理

1. 1
   温度This solution was heated at 75°-80° for 18 hours
2. 2
   その他the solvent was then removed at reduced pressure
3. 3
   その他The residue oil was chromatographed on silica gel
4. 4
   洗浄eluting with 10% methanol/chloroform

実験手順

To 5.0 g (0.051 m) methyl 2-butynoate in 25 ml absolute ethanol was added 5.0 g (0.055 m) 2,3-dihydroxypropylamine. This solution was heated at 75°-80° for 18 hours and the solvent was then removed at reduced pressure. The residue oil was chromatographed on silica gel, eluting with 10% methanol/chloroform to afford the desired product as a white solid, m.p. 109°-111°. The yield was 5.6 g (59%). ##STR5##

出典