反応 #1989928

反応方程式

paratoluen sulphonate methyl ester

2-fluoropyridine

→

2-fluoro-1-methylpyridinium tosylate

収率 95.0%

反応条件

後処理

1. 1
   その他2-fluoro-1-methylpyridinium tosylate is prepared
2. 2
   温度cooling the heated mixture

実験手順

2-fluoro-1-methylpyridinium tosylate is prepared by adding 18.6 g (0.1 mol.) of paratoluen sulphonate methyl ester to 9.7 g (0.1 mol.) of 2-fluoropyridine, heating the resultant mixture for about 20 minutes at 120° C. and cooling the heated mixture to yield 25 g of crystalline 2-fluoro-1-methylpyridinium tosylate (95%). This crystalline starting material is subsequently washed with ether and then dried.

出典