反応 #1988

反応方程式

K2CO3

compound

2-benzyl-4,6-dioxooctahydropyrrolo[3.4-c]pyridine

benzyl bromide

→

title compound

収率 111.4%

2,5-dibenzyl-4,6-dioxooctahydropyrrolo[3.4-c]pyridine

収率 111.4%

溶媒

DMF

ethyl acetate

反応条件

後処理

1. 1
   洗浄was washed with water and brine
2. 2
   その他dried
3. 3
   濃縮concentrated

実験手順

To a mixture of 905 mg of K2CO3 and 400 mg of the compound from step 457b in 5 mL of DMF was added 308 mg of benzyl bromide, and the reaction mixture was stirred at room temperature under N2 for 6.5 hours. The mixture was diluted with ethyl acetate, which was washed with water and brine, dried and concentrated to give 610 mg of the title compound.

出典