反応 #1985940

反応方程式

vanillin

triethylamine

acetic anhydride

→

desired product

4-Acetoxy-3-methoxybenzaldehyde

溶媒

ether

methylene chloride

反応条件

後処理

1. 1
   洗浄the solution washed with water, brine
2. 2
   乾燥dried over magnesium sulfate
3. 3
   ろ過filtered
4. 4
   濃縮concentrated in vacuo

実験手順

A solution of vanillin (60.8 g), triethylamine (60 ml), acetic anhydride (44 ml), and 4-dimethylaminopyridine (1.0 g) in methylene chloride (800 ml) is stirred at room temperature for about 30 minues, and the volume then reduced by 50% in vacuo. The residue is diluted with ether and the solution washed with water, brine, dried over magnesium sulfate, filtered and concentrated in vacuo to give the desired product.

出典