反応 #1985488

反応方程式

2,6-dimethylpyridin-3-amine

thiophosgene

N-ethyl di-isopropyl amine

→

desired product

収率 66.4%

3-Isothiocyanato-2,6-dimethylpyridine

収率 66.4%

溶媒

DCM

反応条件

後処理

1. 1
   その他The title compound was prepared

実験手順

The title compound was prepared following the procedure described for intermediate-2 using 2,6-dimethylpyridin-3-amine (1.0 g, 8.26 mmol), thiophosgene (0.949 g, 8.25 mmol) and N-ethyl di-isopropyl amine (3.20 g, 24.80 mmol) in DCM (20 mL) to afford 0.900 g of the desired product. 1HNMR (DMSO-d6): δ 2.44 (s, 6H), 7.18 (d, J=8.1 Hz, 1H), 7.70 (t, J=8.1 Hz, 1H); MS [M+H]+: 165.28.

出典