反応 #1982

反応方程式

2-(trifluoromethyl)acrylic acid

N-benzyl-N-(methoxymethyl)-trimethylsilylmethylamine

trifluoroacetic acid

→

title product

1-benzyl-3-trifluoromethylpyrrolidine-3-carboxylic acid

溶媒

methylene chloride

methylene chloride

反応条件

後処理

1. 1
   その他The product was removed by filtration
2. 2
   洗浄washed
3. 3
   その他dried

実験手順

A 2.48 g sample of 2-(trifluoromethyl)acrylic acid was dissolved in 40 mL of dry methylene chloride, and a solution of 4.75 g of N-benzyl-N-(methoxymethyl)-trimethylsilylmethylamine in 20 mL of dry methylene chloride was added dropwise under N2 at 0° C. To this mixture was added 2 mL of trifluoroacetic acid, and the mixture was stirred for 2 hours at room temperature. The product was removed by filtration, washed and dried to give the title product.

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