反応 #1981

ord-e4fd5c455c0c484e90968bd95fad35ab

反応方程式

CC(C)(C)OC(=O)N(CCF)C1CCN(Cc2ccccc2)C1
compound
CC(C)(C)OC(=O)N(CCF)C1CCN(Cc2ccccc2)C1
1-benzyl-3-(N-BOC-N-(2-fluoroethyl)amino)pyrrolidine
O=C[O-].[NH4+]
ammonium formate
→
CC(C)(C)OC(=O)N(CCF)C1CCNC1
title compound
CC(C)(C)OC(=O)N(CCF)C1CCNC1
3-(N-BOC-N-(2-fluoroethyl)amino)pyrrolidine

反応物

CC(C)(C)OC(=O)N(CCF)C1CCN(Cc2ccccc2)C1
compound
CC(C)(C)OC(=O)N(CCF)C1CCN(Cc2ccccc2)C1
1-benzyl-3-(N-BOC-N-(2-fluoroethyl)amino)pyrrolidine
O=C[O-].[NH4+]
ammonium formate

試薬

[Pd]
Pd/C

反応条件

詳細条件
See reaction.notes.procedure_details.

実験手順

A 225 mg sample of the compound from step 448a was treated with ammonium formate and 10% Pd/C according to the procedure of step 445b for 1 hour, and the title compound was isolated (190 mg).

出典

DOI: 10.6084/m9.figshare.5104873.v1特許: US05726182uspto-grants-1998_03