反応 #1980

反応方程式

compound

1-benzyl-3-(2,2,2-trifluoroacetyl)aminopyrrolidine

LAH

→

title compound

1-benzyl-3-(2,2,2-trifluoroethyl)aminopyrrolidine

溶媒

ether

反応条件

後処理

1. 1
   workup.STIRRINGthe reaction was stirred at room temperature for 6 hours
2. 2
   その他The reaction was quenched by sequential addition of 1.2 mL of water, 1.2 mL of 15% NaOH and 2.4 mL of water
3. 3
   ろ過The mixture was filtered
4. 4
   濃縮the filtrate was concentrated

実験手順

A 2.64 g sample of the compound from step 447a was added dropwise to a suspension of 1.11 g of LAH in ether stirred under N2 at 0° C. After one hour, the reaction was stirred at room temperature for 6 hours. The reaction was quenched by sequential addition of 1.2 mL of water, 1.2 mL of 15% NaOH and 2.4 mL of water. The mixture was filtered, and the filtrate was concentrated to give 2.39 of the title compound.

出典