反応 #1973986

反応方程式

5-Bromoindoline

sodium hydride

Methanesulfonyl chloride

→

title compound

収率 61.0%

5-bromo-1-(methylsulfonyl)indoline

収率 61.0%

溶媒

DMF

反応条件

後処理

1. 1
   workup.STIRRINGthe solution was stirred at room temperature for 30 min
2. 2
   workup.STIRRINGthe solution stirred at room temperature overnight
3. 3
   濃縮concentrated in vacuo
4. 4
   その他The crude product was purified by column chromatography on silica gel eluting with 2% CH3OH/CHCl3

実験手順

To DMF (5.0 ml) was added sodium hydride (53 mg, 1.3 mmol) and the solution stirred at room temperature for 30 min. 5-Bromoindoline (240 mg, 1.2 mmol) was added and the solution was stirred at room temperature for 30 min. Methanesulfonyl chloride (94 ul, 1.2 mmol) was added and the solution stirred at room temperature overnight, then concentrated in vacuo. The crude product was purified by column chromatography on silica gel eluting with 2% CH3OH/CHCl3 to give the title compound (202 mg, 60%).

出典