反応 #1973974

反応方程式

ethyl thioglycolate

4-bromo-2-fluorobenzaldehyde

triethylamine

→

title compound

収率 92.0%

ethyl 6-bromobenzo[b]thiophene-2-carboxylate

収率 92.0%

溶媒

DMSO

反応条件

後処理

1. 1
   その他The mixture was partitioned between H2O (50 mL) and CH2Cl2 (2×50 mL)
2. 2
   乾燥the combined organic layers were dried over Na2SO4
3. 3
   ろ過The drying agent was filtered off
4. 4
   その他the solvent was removed in vacuo

実験手順

A solution of ethyl thioglycolate (0.65 g, 5.42 mmol), 4-bromo-2-fluorobenzaldehyde (1.0 g, 4.93 mmol) and triethylamine (1.25 mL, 12.3 mmol) in DMSO (5 mL) was heated at 75° C. for 2 h. The mixture was partitioned between H2O (50 mL) and CH2Cl2 (2×50 mL), and the combined organic layers were dried over Na2SO4. The drying agent was filtered off, and the solvent was removed in vacuo to give the title compound as an oil (1.29 g, 92%).

出典