反応 #1973973

反応方程式

methyl 4-bromo-2-(bromomethyl)benzoate

(2,4-dimethoxyphenyl)methanamine

triethylamine

→

title compound

収率 44.2%

5-bromo-2-(2,4-dimethoxybenzyl)isoindolin-1-one

収率 44.2%

溶媒

THF

反応条件

後処理

1. 1
   ろ過The resulting solid was filtered off
2. 2
   濃縮the filtrate was concentrated in vacuo
3. 3
   その他The crude product was purified by column chromatography on silica gel using 1:4 EtOAc

実験手順

To a solution of methyl 4-bromo-2-(bromomethyl)benzoate (1.0 g, 3.25 mmol) and (2,4-dimethoxyphenyl)methanamine (0.65 g, 3.90 mmol) in THF (16 mL) was added triethylamine (0.91 mL, 6.5 mmol), and the resulting mixture was stirred at room temperature for 16 h. The resulting solid was filtered off, and the filtrate was concentrated in vacuo. The crude product was purified by column chromatography on silica gel using 1:4 EtOAc:hexanes as the eluent to give the title compound as a colorless solid (0.52 g, 44%).

出典