反応 #1973971

反応方程式

sodium hypochlorite

hydroxide

sodium iodide

sodium iodide

sodium hypochlorite

HCl

Sodium hydroxide

sodium thiosulfate

2-tert-butylphenol

→

oil

収率 162.4%

2-tert-butyl-4-iodophenol

収率 162.4%

溶媒

MeOH

反応条件

後処理

1. 1
   その他to give a colorless solution
2. 2
   workup.DISSOLUTIONwas completely dissolved
3. 3
   workup.STIRRINGstirred for 30 min
4. 4
   抽出The mixture was extracted 3× with EtOAc
5. 5
   洗浄washed with brine
6. 6
   乾燥dried (MgSO4)
7. 7
   ろ過filtered
8. 8
   濃縮concentrated
9. 9
   その他chromatographed on an ISCO 80 g silica cartridge
10. 10
    洗浄eluting with hexane

実験手順

To a 250 mL round-bottom flask was added 2-tert-butylphenol (3.76 g, 25 mmol) in MeOH (50.0 ml) to give a colorless solution. Sodium hydroxide (1.200 g, 30.0 mmol) was added and the mix was stirred until the hydroxide was completely dissolved. The solution was cooled to 0° C. and treated with sodium iodide (1.75 g, 11.6 mmol) followed by dropwise addition of 10% sodium hypochlorite solution (7.2 ml, 11.6 mmol). The addition of sodium iodide followed by sodium hypochlorite was repeated twice and the mixture was stirred at 0° C. for 30 min. The mixture was treated with 10% w/w solution of sodium thiosulfate, stirred for 30 min and treated with concentrated HCl dropwise to a constant pH of 1. The mixture was extracted 3× with EtOAc. The extracts were combined, washed with brine, dried (MgSO4), filtered and concentrated. The crude oil was flash chromatographed on an ISCO 80 g silica cartridge eluting with hexane-->4:1 hexane/EtOAc to give a yellow oil (5.2 g, 75%).

出典