反応 #1973962

反応方程式

product

methyl 3-tert-butyl-2-hydroxy-5-nitrobenzoate

toluene

acrylic acid

acrylic acid

→

crude title compound

3-(3-tert-butyl-4-methoxy-5-(methoxycarbonyl)phenylamino) propanoic acid

反応条件

後処理

1. 1
   温度This mixture was heated
2. 2
   温度to reflux
3. 3
   workup.ADDITIONadded every 3 h
4. 4
   温度The mixture was then refluxed for 24 h
5. 5
   温度The mixture was then cooled
6. 6
   濃縮concentrated under vacuum to dryness

実験手順

The product from Example 5, Part C (16.44 g, 69.3 mmol) was dissolved in toluene (200 mL). This mixture was heated to reflux and acrylic acid added over time (1 mL of acrylic acid added every 3 h, 5.23 mL total, 76.2 mmol). The mixture was then refluxed for 24 h. The mixture was then cooled and concentrated under vacuum to dryness to yield an oil as the crude title compound that was used directly in the next reaction.

出典