反応 #1973924

反応方程式

Bupivacaine hydrochloride

sodium hydroxide

→

Bupivacaine

溶媒

water

反応条件

後処理

1. 1
   その他to precipitate the Bupivacaine base
2. 2
   ろ過The precipitated product was filtered
3. 3
   洗浄further washed with DI water for at least three times
4. 4
   その他The precipitated product was dried at ca. 40° C. in vacuum for 24 hours

実験手順

Bupivacaine hydrochloride (Sigma-Aldrich Corporation, St. Louis, Mo.) was dissolved in de-ionized (DI) water at a concentration of 40 mg/ml (saturation). A calculated amount of sodium hydroxide (in the form of 1 N solution) was added to the solution and the pH of the final mixtures was adjusted to ten to precipitate the Bupivacaine base. The precipitated product was filtered, and further washed with DI water for at least three times. The precipitated product was dried at ca. 40° C. in vacuum for 24 hours.

出典