反応 #1969

反応方程式

product

4-Chloro-3,5-difluoro-2-(1-(2-tetrahydropyranyl)oxy-2-propyl)pyridine

water

acetic acid

→

title compound

4-Chloro-3,5-difluoro-2-(1-hydroxy-2-propyl)pyridine

溶媒

THF

反応条件

後処理

1. 1
   その他The THF is removed under reduced pressure
2. 2
   抽出is then extracted with methylene chloride
3. 3
   乾燥The organic layer is dried over anhydrous sodium sulfate
4. 4
   ろ過filtered
5. 5
   濃縮concentrated in vacuo

実験手順

The product of Step 1 is dissolved in 200 mL of 2:1 THF:water and to this solution is added 6 mL of acetic acid. The reaction mixture is heated at 45° C. for approximately 5 hours. The THF is removed under reduced pressure and the aqueous reaction mixture is adjusted to a pH in the range of 8 to 9 with 10% sodium carbonate and is then extracted with methylene chloride. The organic layer is dried over anhydrous sodium sulfate, filtered and concentrated in vacuo to afford the title compound.

出典