反応 #1960537

反応方程式

2-hydroxyethyl-p-toluenesulfonate

6-bromo-2-(4′-hydroxyphenyl)imidazo[1,2-a]pyridine

triphenylphosphine

diisopropylazodicarboxylate

→

6-bromo-2-[4′-(2″-p-toluenesulfonyloxyethoxy)phenyl]imidazo[1,2-a]pyridine

収率 12.2%

溶媒

N,N-dimethylformamide

chloroform

反応条件

後処理

1. 1
   workup.DISSOLUTIONto completely dissolve the contents
2. 2
   濃縮the reaction solution was concentrated
3. 3
   その他The resulting crude product was purified by flash silica gel column chromatography (elution solvent: hexane/ethyl acetate=65/35)
4. 4
   ろ過Insoluble matter in chloroform was filtered out of fractions
5. 5
   workup.ADDITIONcontaining a target compound
6. 6
   その他Further, the resulting crude product was purified by recycle preparative HPLC (HPLC apparatus

実験手順

To 10 mL of a solution of 639 mg (corresponding to 2.95 mmol) of 2-hydroxyethyl-p-toluenesulfonate in tetrahydrofran, 388 mg (corresponding to 1.34 mmol) of 6-bromo-2-(4′-hydroxyphenyl)imidazo[1,2-a]pyridine and 780 mg (corresponding to 2.97 mmol) of triphenylphosphine were added. Further, 6 mL of N,N-dimethylformamide was added thereto to completely dissolve the contents. To the reaction mixture, 0.58 mL (corresponding to 2.95 mmol) of diisopropylazodicarboxylate was added. After the reaction mixture was stirred at room temperature for 17 hours, the reaction solution was concentrated. The resulting crude product was purified by flash silica gel column chromatography (elution solvent: hexane/ethyl acetate=65/35). Insoluble matter in chloroform was filtered out of fractions containing a target compound. Further, the resulting crude product was purified by recycle preparative HPLC (HPLC apparatus: LC-908 (under trade name; manufactured by Japan Analytical Industry Co., Ltd.); column: two JAIGEL 2H (under trade name; manufactured by Japan Analytical Industry Co., Ltd.) connected together; mobile phase: chloroform), to obtain 79.7 mg (corresponding to 164 μmol) of 6-bromo-2-[4′-(2″-p-toluenesulfonyloxyethoxy)phenyl]imidazo[1,2-a]pyridine (FIG. 1-3, Step 4).

出典