反応 #1960536

反応方程式

potassium iodide

p-toluenesulfonylchloride

ethylene glycol

→

2-hydroxyethyl-p-toluenesulfonate

収率 29.7%

溶媒

methylene chloride

反応条件

後処理

1. 1
   ろ過Insoluble matters were filtered out of the reaction mixture
2. 2
   洗浄were washed with ethyl acetate
3. 3
   濃縮the mixture was concentrated
4. 4
   その他The resulting crude product was purified by flash silica gel column chromatography (elution solvent: hexane/ethyl acetate=1/1)

実験手順

621 mg (corresponding to 10.0 mmol) of ethylene glycol was dissolved in 100 mL of methylene chloride. To this solution under an ice bath, 3.49 g (corresponding to 15.0 mmol) of silver oxide, 350 mg (corresponding to 2.1 mmol) of potassium iodide and 2.10 g (corresponding to 11.0 mmol) of p-toluenesulfonylchloride were added. The resulting mixture was stirred at 0° C. for 2 hours. Insoluble matters were filtered out of the reaction mixture, and were washed with ethyl acetate. The washings were combined with the filtrate, and the mixture was concentrated. The resulting crude product was purified by flash silica gel column chromatography (elution solvent: hexane/ethyl acetate=1/1) to obtain 643 mg (corresponding to 2.97 mmol) of 2-hydroxyethyl-p-toluenesulfonate (FIG. 1-3, Step 3).

出典