反応 #1960533

反応方程式

6-bromo-2-(4′-hydroxyphenyl)imidazo[1,2-a]pyridine

potassium carbonate

3-bromo-1-propanol

→

6-bromo-2-[4′-(3″-hydroxypropoxy)phenyl]imidazo[1,2-a]pyridine

収率 73.4%

溶媒

water

反応条件

後処理

1. 1
   その他to remove moisture
2. 2
   workup.DISSOLUTIONwas dissolved in 50 mL of N,N-dimethylformamide
3. 3
   その他After the completion of the reaction
4. 4
   抽出extracted three times with chloroform
5. 5
   洗浄The combined chloroform layer was washed with a saturated sodium chloride solution
6. 6
   乾燥dried over anhydrous sodium sulfate
7. 7
   ろ過filtered
8. 8
   濃縮concentrated
9. 9
   その他The resulting crude product was recrystallized from methanol

実験手順

1.45 g (corresponding to 5.0 mmol) of 6-bromo-2-(4′-hydroxyphenyl)imidazo[1,2-a]pyridine that was sufficiently dried to remove moisture was dissolved in 50 mL of N,N-dimethylformamide, and 2.07 g (corresponding to 15.0 mol) of potassium carbonate was added thereto. The mixture was supplemented with 680 μL (corresponding to 7.5 mmol) of 3-bromo-1-propanol, and then the solution was stirred at room temperature for 17 hours. After the completion of the reaction, the reaction solution was poured into water and extracted three times with chloroform. The combined chloroform layer was washed with a saturated sodium chloride solution, dried over anhydrous sodium sulfate, filtered and concentrated. The resulting crude product was recrystallized from methanol to obtain 1.28 g (corresponding to 3.67 mmol) of 6-bromo-2-[4′-(3″-hydroxypropoxy)phenyl]imidazo[1,2-a]pyridine (FIG. 1-2, Step 3).

出典