反応 #1960529

反応方程式

6-iodoimidazo[1,2-a]pyridine

bis(tributyltin)

triethylamine

→

imidazo[1,2-a]pyridine

溶媒

dioxane

反応条件

後処理

1. 1
   その他reacted for about 24 hours
2. 2
   workup.DISTILLATIONa solvent is distilled off
3. 3
   その他chromatographic purification

実験手順

The obtained 2-[4′-(2″-hydroxyethoxy)]phenyl]-6-iodoimidazo[1,2-a]pyridine was dissolved in dioxane, and triethylamine is added thereto. Then, bis(tributyltin) and a catalytic amount of tetrakis-triphenylphosphine palladium are added thereto. This reaction mixture is heated at about 90° C. and reacted for about 24 hours, and then a solvent is distilled off and chromatographic purification is performed to obtain 6-tributylstannyl-2-[4′-(2″-hydroxyethoxy)]phenyl]imidazo[1,2-a]pyridine as the target compound (FIG. 2-2, Step 1). The amount of bis(tributyltin) to be used in this instance may be an amount satisfying a condition where it is excessive relative to the reaction substrate, specifically, it is about 1.5 times in molar ratio relative to the reaction substrate 2-[4′-(2″-hydroxyethoxy)phenyl]-6-iodoimidazo[1,2-a]pyridine.

出典