反応 #1960521

反応方程式

Salicylaldehyde

pyridine

bromoacetyl bromide

→

bromo-acetic acid 2-formyl-phenyl ester

収率 60.3%

溶媒

dichloromethane

反応条件

後処理

1. 1
   洗浄The reaction mixture was washed with 1000 ml of water and 1500 ml of 5% sodium bicarbonate solution
2. 2
   乾燥dried over sodium sulphate
3. 3
   workup.DISTILLATIONfollowed by distillation of solvent under reduced pressure

実験手順

To a solution of Salicylaldehyde (50 grams) and pyridine (48.5 grams) in dichloromethane (500 ml) maintained at 0-5° C. under nitrogen atmosphere was added dropwise bromoacetyl bromide (210.6 grams). The reaction mixture was stirred for one hour at the same temperature. The reaction mixture was washed with 1000 ml of water and 1500 ml of 5% sodium bicarbonate solution, dried over sodium sulphate followed by distillation of solvent under reduced pressure to get 60.0 grams of bromo-acetic acid 2-formyl-phenyl ester.

出典