反応 #1957755

反応方程式

water

(E)-3-(2-hydroxy-phenyl)-2-methyl-acrylic acid

citronellol

p-toluene-sulfonic acid

→

colourless oil

収率 60.5%

(E)-3-(2-Hydroxy-phenyl)-2-methyl-acrylic acid 3,7 dimethyl-oct-6-enyl ester

収率 60.5%

溶媒

hexane

cyclohexane

反応条件

後処理

1. 1
   温度Then the reaction mixture was cooled down
2. 2
   洗浄washed
3. 3
   その他The organic phase was dried
4. 4
   ろ過filtered
5. 5
   その他evaporated to dryness
6. 6
   その他The resulting yellow oil was purified by chromatography

実験手順

A solution of 6.0 g of (E)-3-(2-hydroxy-phenyl)-2-methyl-acrylic acid, 5.3 g of citronellol and 1 g of p-toluene-sulfonic acid in 150 ml of cyclohexane was refluxed for 6.5 hours using a water separator. Then the reaction mixture was cooled down, diluted with hexane and washed to neutrality with saturated sodium bicarbonate and water. The organic phase was dried, filtered and evaporated to dryness. The resulting yellow oil was purified by chromatography to yield 6.45 g of a colourless oil.

出典