反応 #1956

反応方程式

sulfuric acid

4-Chloro-5-fluoro-2-picoline

product

4-Chloro-5-fluoro-2-picoline

bromine

→

title compound

3-Bromo-4-chloro-5-fluoro-2-picoline

反応条件

後処理

1. 1
   その他for 7 hours
2. 2
   その他at 80° C.

実験手順

4-Chloro-5-fluoro-2-picoline, the product of Example 66, is treated with bromine in fuming sulfuric acid containing 65% sulfur trioxide for 7 hours at 80° C. as described by L. van der Does and H. J. Hertog in Rec Trav Chim 81: 864 (1965) to afford the title compound.

出典