反応 #1955

反応方程式

water

4-chloro-5-fluoro-2-picoline

product

4-Chloro-5-fluoro-2-picoline

t-butylhypochlorite

→

title compound

3,4-Dichloro-5-fluoro-2-picoline

溶媒

chloroform

反応条件

後処理

1. 1
   抽出the resultant aqueous mixture is extracted with methylene chloride
2. 2
   乾燥The organic solution is dried over anhydrous magnesium sulfate
3. 3
   ろ過filtered
4. 4
   濃縮concentrated under reduced pressure
5. 5
   workup.DISTILLATIONdistilled

実験手順

To 0.87 g (6 mmol) of 4-chloro-5-fluoro-2-picoline, the product of Example 66, in 20 mL of chloroform cooled to -45° C., is added 0.75 mL of t-butylhypochlorite. The reaction mixture is stirred at -45° C. for 2 hours and at 0° C. for 2 hours. The reaction mixture is then poured into water and the resultant aqueous mixture is extracted with methylene chloride. The organic solution is dried over anhydrous magnesium sulfate, filtered, concentrated under reduced pressure and distilled to afford the title compound.

出典