反応 #1952946
ord-bf016e22225846a3a8f3a36c8e5887cd
反応条件
後処理
- 1その他were prepared
- 2その他Pre-spray drying solutions
- 3その他were prepared
- 4濃縮Final total solute concentration of the solution
- 5その他drying
- 6その他was prepared
- 7workup.ADDITIONmixing the two solutions
- 8その他to yield one liter of cosolvent with a total solute concentration of 1 g/L (w/v)
- 9濃縮Higher solute concentrations of 3 g/L (w/v)
- 10その他were prepared
- 11その他The solution was spray-dried
- 12workup.ADDITIONcontaining formulation
- 13その他was from about 110° C. to about 140° C.
- 14その他ranged from about 45-57° C.
実験手順
The albuterol sulfate powder formulations listed in Table 7, were prepared as follows. Pre-spray drying solutions were prepared by dissolving the lipid in ethanol and albuterol sulfate and leucine in water. The ethanol solution was then mixed with the water solution at a ratio of 70/30 ethanol/water. Final total solute concentration of the solution used for spray drying varied from 1 g/L to 3 g/L. As an example, the DPPC/leucine/albuterol sulfate (76/16/8) spray drying solution was prepared by dissolving 760 mg of DPPC in 700 mL of ethanol, dissolving 160 mg leucine and 870 mg of albuterol sulfate in 300 mL water and then mixing the two solutions to yield one liter of cosolvent with a total solute concentration of 1 g/L (w/v). Higher solute concentrations of 3 g/L (w/v) were prepared by dissolving three times more of each solute in the same volumes of ethnaol and water. The solution was spray-dried as described above for the insulin containing formulation. Specifically, the inlet temperature was from about 110° C. to about 140° C., and the outlet temperature ranged from about 45-57° C.