反応 #1951068

反応方程式

Bromotrimethylsilane

4-fluorophenyl-phosphonic acid diethyl ester

→

4-fluorophenyl-phosphonic acid bis(trimethylsilyl) ester

反応条件

後処理

1. 1
   温度to warm to ambient temperature
2. 2
   workup.STIRRINGstirred for an additional hour
3. 3
   濃縮The mixture was then concentrated by rotary evaporation

実験手順

Bromotrimethylsilane (15.3 mL, 0.116 mol) was added dropwise to 4-fluorophenyl-phosphonic acid diethyl ester (8.95 g, 38.58 mmol) stirred in a reaction flask chilled to 0° C. The resulting solution was allowed to warm to ambient temperature and stirred for an additional hour. The mixture was then concentrated by rotary evaporation yielding crude 4-fluorophenyl-phosphonic acid bis(trimethylsilyl) ester which was used in the next step without further purification.

出典