反応 #1947788

反応方程式

2′-phthalimidomethylbiphenyl-2-carboxylic acid

isopentylamine

HOBT

DIC

→

2′-phthalimidomethylbiphenyl-2-carboxylic acid isopentylamide

反応条件

実験手順

From 3 g (8.4 mmol) of 2′-phthalimidomethylbiphenyl-2-carboxylic acid (precursor 2), by reaction with isopentylamine in the presence of HOBT and DIC, 3.2 g of 2′-phthalimidomethylbiphenyl-2-carboxylic acid isopentylamide were obtained; m.p. 169° C. The product was dissolved in 100 ml of methanol and treated with 5 ml of hydrazine hydrate. After stirring at 40° C. for 1 h, the cooled reaction mixture was filtered. The filtrate was concentrated and the residue was taken up in methylene chloride. After washing with water, drying and concentrating, 1.8 g of 2′-amino-methylbiphenyl-2-carboxylic acid isopentylamide were obtained.

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