反応 #1946562

反応方程式

potassium 1-amino-5-cyano-2-hydroxy-4-methyl-6-pyridone

benzoyl chloride

→

1-Benzoylamino-5-cyano-2-hydroxy-4-methyl-6-pyridone

溶媒

water

methylene chloride

反応条件

後処理

1. 1
   ろ過filtered
2. 2
   洗浄The solid was washed with isopropanol and air
3. 3
   その他dried

実験手順

To a solution of 10.16 g (50 mmol) of potassium 1-amino-5-cyano-2-hydroxy-4-methyl-6-pyridone in 50 ml of water was added a solution of 7.03 g (50 mmol) of benzoyl chloride in 50 ml of methylene chloride. The mixture was stirred rapidly for 1 hr, and then filtered. The solid was washed with isopropanol and air dried. The yield of product was 3.90 g (29.0%); mp: 256° C. dec. The NMR spectrum was consistent with the proposed structure. Anal. Calcd. for C14H11N3O3: C, 62.5; H, 4.1; N, 15.6. Found: C, 62.23; H, 4.31; N, 15.85.

出典