反応 #1946544

反応方程式

N-Bromosuccinimide

benzoyl peroxide

p-Toluene boronic acid

neopentyl glycol

→

p-bromomethyl phenyl boronic acid-neopentyl ester

溶媒

cyclohexane

cyclohexane

反応条件

後処理

1. 1
   温度heated
2. 2
   温度at reflux for 1.5 hours
3. 3
   温度the solution was heated
4. 4
   温度at reflux for additional 2 hours
5. 5
   ろ過filtered
6. 6
   その他evaporated
7. 7
   その他to give

実験手順

p-Toluene boronic acid (750 mg.) and neopentyl glycol (600 mg.) were dissolved in 50 ml cyclohexane and heated at reflux for 1.5 hours. N-Bromosuccinimide (1.15 g.), benzoyl peroxide (25 mg.) and 150 ml cyclohexane were added and the solution was heated at reflux for additional 2 hours. The solution was cooled to room temperature, filtered and evaporated to give a mixture of 8 and 8a (total of 1.3 g, ˜1:1 ratio), the yield of 8=47%.

出典