反応 #1945

反応方程式

LDA

LDA

hexane

product

nitric acid

ethyl iodide

4-chloro-2-picoline

→

title compound

収率 60.0%

4-Chloro-2-propyl-pyridine

収率 60.0%

溶媒

THF

THF

反応条件

後処理

1. 1
   workup.STIRRINGAfter the reaction mixture was stirred at -60° C. for 0.5 hours
2. 2
   その他was allowed to slowly (1.5 hours)
3. 3
   温度warm to -30° C
4. 4
   洗浄eluted with 5% methanol in methylene chloride
5. 5
   workup.ADDITIONThe reaction mixture was poured into cold brine
6. 6
   抽出the aqueous mixture was extracted with methylene chloride
7. 7
   抽出The organic extract
8. 8
   乾燥was dried over anhydrous sodium sulfate
9. 9
   ろ過filtered
10. 10
    濃縮concentrated in vacuo
11. 11
    workup.DISTILLATIONThe residue was distilled

実験手順

A 1.5M solution of LDA in hexane (100 mL, 150 mmol) was cooled to -60° C. in an isopropyl alcohol/dry ice bath. To the stirred LDA solution, under nitrogen, was added, dropwise over a 0.5 hours period, a solution of 17.466 g (137 mmol) of 4-chloro-2-picoline (the product of Step 1 of Example 58) in 80 mL of dry THF. The reaction mixture was stirred for 0.5 hours at -60° C. and then a solution of 10.95 mL (137 mmol) of ethyl iodide in 30 mL of dry THF was added, dropwise over a 20 minute period. After the reaction mixture was stirred at -60° C. for 0.5 hours, the cooling bath was allowed to slowly (1.5 hours) warm to -30° C. According to TLC analysis on silica gel eluted with 5% methanol in methylene chloride, the reaction had gone to completion. The reaction mixture was poured into cold brine and the aqueous mixture was extracted with methylene chloride. The organic extract was dried over anhydrous sodium sulfate, filtered and concentrated in vacuo. The residue was distilled to afford 12.667 g (60% yield of the title compound, b.p. 77°-80° C. (10 mm Hg).

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